TRPC6 COUNTERACTS TRPC3-NOX2 PROTEIN COMPLEX LEADING TO ATTENUATION OF HYPERGLYCEMIA-INDUCED HEART FAILURE IN MICE

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

Abstract Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure.We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive cardiac fibrosis by forming stably functional complex with NADPH oxidase 2 (Nox2).Although TR

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Risk of incident sleep disorders in patients with prurigo nodularis: A population-level analysis using The Health Improvement NetworkCapsule Summary

Background: Prurigo nodularis (PN) is a chronic inflammatory skin condition characterized by severely itchy and often painful bumps on the arms, legs, and trunk.It is unknown whether patients with PN have increased risk of developing sleep disorders.Objective: moen finney To evaluate the association of PN with sleep disorders.Methods: This retrospe

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